Research

RESEARCH

Publicaties en nieuwsoverzicht

‘It Doesn’t Smell Like Cancer to Me, the Promise of Exhaled Breath Biomarkers for Lung Cancer Diagnosis’

Editorial in Chest

22-03-23

The eNose Company aanwezig op HIMSS in Chicago, 17-21 april, 2023

Op de ‘Healthcare Information and Management Systems Society (HIMSS)’ Global Health Conference & Exhibition in Chicago, zullen wij de longkanker-toepassing van de aeoNose™ demonstreren gebruikmakend van het IRIS4Health Intersystems platform voor communicatie met het Elektronische Patiënten Dossier (EPD).
21-03-23

Promotie Rens van de Goor

Op 3 maart jl. heeft Rens van de Goor, KNO-chirurg in ziekenhuis Bernhoven te Uden, met succes zijn proefschrift verdedigd, getiteld ‘Non-invasive diagnostic of head and neck cancer: feasibility of a portable electronic nose’.

‘Diagnosing Non-Small Cell Lung Cancer by Exhaled-Breath Profiling Using an Electronic Nose: A Multicenter Validation Study”

S. Kort,
M. Brusse-Keizer,
H. Schouwink,
E. Citgez,
F.H. de Jongh,
J.W.G. van Putten,
B. van den Borne,
E.A. Kastelijn,
D. Stolz,
M. Schuurbiers,
M.M. van den Heuvel,
W.H. van Geffen,
J. van der Palen

19-10-22

Longkanker opsporen met elektronische neus

Is het mogelijk om aan uitademingslucht van mensen te ruiken of zij longkanker hebben? Sharina Kort, longarts in opleiding in MST, promoveerde onlangs aan de Universiteit Twente (Technisch Medisch Centrum) op haar onderzoek hiernaar.
10-10-22

The eNose Company is genomineerd voor Nederlandse Innovatie Prijs 2022

De winnaar wordt op woensdagavond 2 november op NPO1 bekend gemaakt tijdens het tv-programma 'De wereld van morgen' van AVROTROS.

Resultaten van studie gepresenteerd op ERS Barcelona

Sharina Kort MD, PhD presenteerde de resultaten van de studie ‘Diagnosing non-small cell lung cancer by exhaled breath profiling using an electronic nose: A multicenter validation study’ op het ERS congres 2022 in Barcelona. Met behulp van de aeoNose konden longkankerpatiënten niet-invasief worden onderscheiden van niet-longkankerdeelnemers in een multinationale validatieomgeving. Een paper over deze studie is onlangs aanvaard door 'Chest'.

Using a stepwise approach to simultaneously develop and validate Machine Learning based prediction models

M. Haalboom
S. Kort
J. van der Palen

Identifying COVID-19-infected healthcare workers using an electronic ‘nose’

Steef Kurstjens
Noemí García-Tardón
Marion Fokkert
Wouter van Geffen
Robbert Slingerland
Job van der Palen
Ron Kusters

Feasibility of a Portable Electronic Nose for Oral Squamous Cell Carcinoma Screening in Sudan

Nazar Gafar Mohamed
Rens M.G.E. van de Goor
Mariam El-Sheikh
Osman Elrayah
Elisabeth Sivy Nginamau
Anne Christine Johannessen
Ahmed Suleiman
Daniela Elena Costea
Kenneth Kross

Volatile organic compounds in breath can serve as a non-invasive diagnostic biomarker for the detection of advanced adenomas and colorectal cancer

K.E. van Keulen
M.E. Jansen
R.W.M. Schrauwen
J.J. Kolkman
P.D. Siersema

Data analysis of electronic nose technology in lung cancer: Generating prediction models by means of Aethena

S. Kort
M. Brusse-Keizer
JW. Gerritsen
J. Van der Palen

Improving lung cancer diagnosis by combining exhaled-breath data and clinical parameters

S. Kort
M. M. Brusse-Keizer
J.W. Gerritsen
J.H. Schouwink
E. Citgez
F.H.C. de Jongh
J. van der Maten
S. Samii
M. Van den Bogart
J. van der Palen

Multi-centre prospective study on diagnosing subtypes of lung cancer by exhaled-breath analysis

S. Kort
M.M. Tiggeloven
M. Brusse-Keizer
J.W. Gerritsen
J.H. Schouwink
E. Citgez
F.H.C. de Jongh
S. Samii
J. van der Maten
M. van den Bogart
J. van der Palen

Training and validating a portable electronic nose for lung cancer screening

R. Van de Goor
M. van Hooren
A.M. Dingemans
B. Kremer
K. Kross

The electronic nose as a rule-out test for tuberculosis in an indigenous population

Rosarito Coronel Teixeira
Dirk IJdema
Cinthia Gómez
Denis Arce
Myrian Roman
Yvamna Quintana
Felipe Gonzalez
Nilda Jiménez de Romero
Domingo Pérez Bejaran
Sarita Aguirre
Cecile Magis-Escurra

10-03-21

Health Valley Event: interview Dolf Jansen met André Elands

Detecting Multiple Sclerosis via breath analysis using an eNose, a pilot study’

Rozemarijn Ettema
Mathieu Lenders
Jos Vliegen
Astrid Slettenaar
Marleen C. Tjepkema-Cloostermans
Cecile de Vos

The role of volatile organic compounds as predictors of treatment response in drug susceptible TB patients: an initial proof of concept study

Rosarito Coronel Teixeira
Sandra Gonzalez Toledo
Miriam Román Acosta
Nilda Jiménez Acuña
Jan Bart Yntema
Domingo Pérez Bejarano
Cecile Magis-Escurra

Development of an Algorithm for Cervical High-Grade Squamous Intraepithelial Lesion based on Breath Print Analyis

L. Dokter
J. Nijeholt
B. Rigterink
N. de Lange
H. de Haan
H. van Eijndhoven
M. Joostens
A-J. Kruse

External validation of exhaled-breath analysis to detect non-small cell lung cancer: a step-wise design to simultaneously develop and validate a prediction model

S. Kort
M. Brusse-Keizer
J.W. Gerritsen
J.H. Schouwink
E. Citgez
F.H.C. de Jongh
D. Stolz
M. van den Heuvel
W. van Geffen,
Martini
L. Kastelijn
B. van den Borne
J. van der Palen

Feasibility of volatile organic compound in breath analysis in the follow-up of colorectal cancer: a pilot study

E.G.M. Steenhuis
I.J.H. Schoenaker
J.W.B. de Groot
H.B. Fiebrich
J.C. de Graaf
R.M. Brohet
J.D. van Dijk
H.L. van Westreenen
P.D. Siersema
W.H. de Vos tot Nederveen Cappel

Detecting head and neck squamous carcinoma using a portable handheld electronic

R.M.G.E van de Goor
M.R.A. van Hooren
D. Henatsch
B. Kremer
K.W. Kross

Guts_eNose
05-05-20

Just published in ‘Gut’, results from a pilot study on Barrett’s oesophagus using the Aeonose

This year, the Union World Conference on Lung Health was held in Hyderabad, India. At the TBScience pre-conference, an official event entirely devoted to basic and translational tuberculosis (TB) research, study results were presented on the Aeonose exhaled-breath tests in Cape Town.

Breath analysis in detecting epilepsy

Dieuwke van Dartel
H. Jurgen Schelhaas
Albert J Colon
Kuan H Kho
Cecile C. de Vos

eNose apt
09-01-20

Multicenter study Colon rectal cancer and advanced adenomas

Timely detection of oesophageal adenocarcinoma (OAC) and even more so its precursor Barrett’s oesophagus (BO) could contribute to decrease OAC incidence and mortality. An accurate, minimally-invasive screening method for BO for widespread use is currently not available. In a proof-of-principle study in 402 patients, we developed and cross-validated a BO prediction model using volatile organic compounds (VOCs) analysis with an electronic nose device. This electronic nose was able to distinguish between patients with and without BO with good diagnostic accuracy (sensitivity 91% specificity 74%) and seemed to be independent of proton pump inhibitor use, the presence of hiatal hernia, and reflux. This technique may enable an efficient, well-tolerated, and sensitive and specific screening method to select high-risk individuals to undergo upper endoscopy.
Op Oost logo
14-11-19

Subsidie toegekend

Subsidieaanvraag gehonoreerd voor project: Van Ademanalyse-Module naar ZorgOplossing (AMZO) De Aeonose is een elektronische neus, die het mogelijk maakt om diverse ziektebeelden te detecteren door middel van ademanalyse. Deze analysemethode is snel en niet-invasief en daarmee ook patiëntvriendelijk.
Aeonose breath analysis on TB screening South Africa
05-11-19

Aeonose breath analysis on TB screening South Africa

This year, the Union World Conference on Lung Health was held in Hyderabad, India. At the TBScience pre-conference, an official event entirely devoted to basic and translational tuberculosis (TB) research, study results were presented on the Aeonose exhaled-breath tests in Cape Town.
eNose peru
04-11-19

Aeonose breath analysis on TB screening Peru

The Union World Conference on Lung Health 2019 was held in Hyderabad (India) from October 30 – November 2. Dr. Ruvandhi Nathavitharana (Harvard University) presented results on the Aeonose exhaled-breath TB-study in Lima, suggesting Aeonose may meet WHO triage test criteria to rule out TB (90% sensitivity, 70% specificity) in lower-risk patients admitted with cough or TB risk factors.
eNose in Business Driesteden Noord-Veluwe
29-10-19

eNose artikel Business

Een draagbare elektronische neus die aan de adem van patiënten kan ruiken of zij een bepaalde aandoening hebben. Fictie? Zeker niet. The eNose Company in Zutphen werkt al vijftien jaar aan de ontwikkeling van de aeoNose, ooit ontwikkeld voor de politie voor het opsporen van wietplantages, nu voor het diagnosticeren van diverse ziektebeelden. Met de komst van krachtiger computers en artificial intelligence krijgt het bedrijf de wind in de rug.
international congress 2019
01-10-19

Improving lung cancer screening results

At the ERS Conference in Madrid (September 28 – October 2, 2019), Sharina Kort (MST, Enschede, the Netherlands) presented clinical study results on diagnosing lung cancer using the Aeonose.
Pancreas new diagnostics
14-08-19

Pancreas new diagnostics

Improved diagnostics for pancreatic diseases are badly needed. An electronic nose (AeoNose™) analysing exhaled breath was successfully used to distinguish between pancreas carcinoma, chronic pancreatitis (inflammation of the pancreas), and healthy controls: promising results from a multicenter pilot study in the Netherlands.
Digestive Disease Week
18-06-19

Presentations at DDW San Diego

At the Digestive Disease Week in San Diego, 4 posters were presented discussing ongoing clinical studies with the Aeonose for exhaled-breath analysis: - Colorectal cancer and advanced adenomas - Barrett’s esophagus (presented both by Radboud University (Nijmegen, the Netherlands) and Mayo Clinic (Rochester)) - Fasting state
Aeonose breath analysis on TB screening Indonesia
17-06-19

Aeonose breath analysis on TB screening Indonesia

Morita Saktiawati, PhD-student working in Yogyakarta, conducted a clinical study in using the Aeonose to detect TB in exhaled breath among TB suspects. Her supervisor was Prof Tjip van der Werf from University Medical Center Groningen, the Netherlands.
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