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19-10-2022

Detecting lung cancer with electronic nose

Is it possible to detect lung cancer by smelling the air that someone exhales? Sharina Kort, lung specialist in training at MST, recently earned a PhD from the University of Twente (TechMed Centre) based on her research into that topic.

Since 2015, Sharina Kort has been researching the potential for diagnosing lung cancer with breath analysis. In the research, an electronic nose is trained to distinguish between people with and without lung cancer.

“Many people die of lung cancer. This is largely because it is discovered only at a late stage, when metastases are generally already present and there is little hope of recovery,” says Sharina. “That’s why our research is so important; another reason is that it focuses on non-invasive lung cancer diagnostics. In other words, a test that does not entail a risk of complications and that is not regarded as unpleasant by the patient.”

That’s why our research is so important; another reason is that it focuses on non-invasive lung cancer diagnostics. In other words, a test that does not entail a risk of complications and that is not regarded as unpleasant by the patient.” Sharina Kort

The nose has been trained at four hospitals, among 376 people, to detect lung cancer in exhaled air. “We subsequently confirmed this in a new group of 199 people,” Sharina adds. “If the nose indicates that no lung cancer is present, we can say with 94% certainty that the person doesn’t have lung cancer.”

“Tests with an e-nose could be a quicker, cheaper and less unpleasant way of detecting lung cancer than the current test methods. At the moment, biopsies are taken from the lung, for example,” Sharina continues. “With e-nose tests you get the results more quickly, so the patient waits in uncertainty for a shorter time.”

“The next step is to determine what stage in the testing process is the best time to use the electronic nose so it provides the most benefits to the patient,” Sharina says. “That needs to be the subject of further research.”

Text and Photo: MST

PhD-defense Michiel Bannier

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Keynote at InterSystems Global Summit 2023

Prof Job van der Palen discussing the prospects of disease screening using an electronic nose.

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The eNose Company will be present at HIMSS in Chicago, April 17-21, 2023

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PhD-defense Rens van de Goor

On March 3rd, Rens van de Goor, otolaryngologist at Bernhoven hospital, Uden, the Netherlands, successfully defended his PhD-thesis ‘Non-invasive diagnostic of head and neck cancer: feasibility of a portable electronic nose’.

Detecting lung cancer with electronic nose

Is it possible to detect lung cancer by smelling the air that someone exhales? Sharina Kort, lung specialist in training at MST, recently earned a PhD from the University of Twente (TechMed Centre) based on her research into that topic.

Results of study presented at ERS Barcelona

Sharina Kort MD, PhD presented the results of the study ‘Diagnosing non-small cell lung cancer by exhaled breath profiling using an electronic nose: A multicentre validation study’ on the ERS congress 2022 in Barcelona. Using the aeoNose, lung cancer patients could non-invasively be distinguished from non-lung cancer participants in a multinational validation setting. A paper on this study has recently been accepted by ‘Chest’.
Aeonose breath analysis on TB screening South Africa

Aeonose breath analysis on TB screening South Africa

This year, the Union World Conference on Lung Health was held in Hyderabad, India. At the TBScience pre-conference, an official event entirely devoted to basic and translational tuberculosis (TB) research, study results were presented on the Aeonose exhaled-breath tests in Cape Town.
Guts_eNose

Just published in ‘Gut’, results from a pilot study on Barrett’s oesophagus using the Aeonose

This year, the Union World Conference on Lung Health was held in Hyderabad, India. At the TBScience pre-conference, an official event entirely devoted to basic and translational tuberculosis (TB) research, study results were presented on the Aeonose exhaled-breath tests in Cape Town.
eNose apt

Multicenter study Colon rectal cancer and advanced adenomas

Timely detection of oesophageal adenocarcinoma (OAC) and even more so its precursor Barrett’s oesophagus (BO) could contribute to decrease OAC incidence and mortality. An accurate, minimally-invasive screening method for BO for widespread use is currently not available. In a proof-of-principle study in 402 patients, we developed and cross-validated a BO prediction model using volatile organic compounds (VOCs) analysis with an electronic nose device. This electronic nose was able to distinguish between patients with and without BO with good diagnostic accuracy (sensitivity 91% specificity 74%) and seemed to be independent of proton pump inhibitor use, the presence of hiatal hernia, and reflux. This technique may enable an efficient, well-tolerated, and sensitive and specific screening method to select high-risk individuals to undergo upper endoscopy.
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